Ms And Mesenchymal Stem Cells

The development of hematopoietic and mesenchymal stem cell transplantation as an effective treatment for multiple sclerosis.

Ms and mesenchymal stem cells. Radaelli m et al. Mscs mesenchymal stem cells adult stem cells found in several places in the body including the bone marrow skin and fat tissue. American journal of stem cells 2013 2 2 95 107. Mscs have been demonstrated to suppress inflammation and repair nerve tissue making them attractive candidates for ms treatment.

The discovered potential of mesenchymal stem cells msc in treating multiple sclerosis ms has culminated in the launch of mescams mesenchymal stem cell therapy for canadian ms patients a phase ii clinical trial that is funded in part by the ms scientific research foundation research manitoba and a w food services of canada inc. Autologous bone marrow transplantation for the treatment of multiple sclerosis. Mark freedman ottawa hospital research. Mesenchymal stem cells mscs also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types including osteoblasts bone cells chondrocytes cartilage cells myocytes muscle cells and adipocytes fat cells which give rise to marrow adipose tissue.

Transplanting patients own mesenchymal stem cells mscs is a safe therapeutic approach and can delay disease progression in people with multiple sclerosis ms a meta analysis review shows. Current neurology and neuroscience reports 2014 14 9 478. Hscs are capable of producing all of the cells that make up the blood and the immune system. They produce cells which help other stem cells function properly.

Most of the reported trials were uncontrolled open label phase i studies and included secondary progressive ms progressive ms relapsing remitting and secondary progressive ms and active but unspecific patients a phase ii trial on secondary progressive ms. Mesenchymal stem cells mscs represent an attractive alternative to develop a cell based therapy for multiple sclerosis. Hscs haematopoietic stem cells adult stem cells that are found in bone marrow and blood. Many types of stem cells are being explored for their potential benefits for treating multiple sclerosis.

Mesenchymal stem cells mesenchymal stem cells msc are found in many places in the body including the bone marrow skin and fat. Mesenchymal stem cells mscs are found in many parts of the body and are usually taken from bone marrow skin and fat tissue. Stem cells and ms multiple sclerosis ms is an inflammatory disease of the central nervous system cns with a strong degenerative component leading to irreversible disability. Mesenchymal stem cells showed effects on innate and adaptive immunity in studies on animal models of multiple sclerosis.

They can produce many different types of cells including muscle and cartilage.